Postdoctoral Scholar, Protein Formulations

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Career Programs

Job Sub Function:

Post Doc – R&D Product Development

Job Category:

Career Program

All Job Posting Locations:

Malvern, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for Postdoctoral Scholar, Protein Formulations in Malvern, PA.

Purpose: This postdoctoral scholar position is an opportunity within the protein formulations group in Drug Product Development & Delivery (DPD&D). This position will be a lab-based role,. The postdoctoral scholar will be responsible for experimental studies to evaluate and characterize the efficacy of molecular chaperones as therapeutic protein stabilizers. Therapeutic proteins to be evaluated include mAbs, bispecifics and multispecifics. This includes development and optimization of the technical operations associated with biologics development, high protein concentration feasibility, molecular chaperone screening, biophysical analysis of protein therapeutics, analysis of small molecule / mAb interactions, protein formulation optimization, and stability campaigns.  Where applicable, the postdoctoral scholar will be exposed to, and potentially assist with, computational evaluation of small molecule / mAb interactions. The postdoctoral scholar will work independently as well as with cross-functional teams to support project needs and meet project deliverables.

You will be responsible for:

• Plan and execute studies to evaluate novel small molecule chaperones for the ability to stabilize large molecule (antibody) assets within the JNJ portfolio.
• Prepare and deliver data-driven presentations to various stakeholders
• Development, training, conferences, internal meetings, and symposia

Qualifications:

Education: Minimum of PhD in in an appropriate scientific field such as Biophysics, Chemistry, Bioengineering is required.

Skills/Experience:

Required:

• Experience using protein biophysical characterization techniques (e.g. DSF, DSC, CD, ITC, NMR)
• Knowledge of analytical / separations techniques commonly used in the analysis of proteins (e.g. SEC, cIEF)
• Ability to interpret protein stability data and identify protein liabilities / mechanism of degradation from biophysical and bioanalytical assays
• Ability to use emerging developments in relevant scientific fields to support new technical and research initiatives focused on formulation / excipient-dependent protein stability
• Communication and collaboration skills with scientifically diverse teams
• Capability to learn and navigate problems with a high degree of independence
• Publication and presentation history and involvement with scientific organizations or conferences

Preferred

While not necessary for this role, prior knowledge/experience in molecular modeling / computational assessment of biopolymers is desired. Preferred skills include some or all of the following:

• Molecular modeling/visualization software (e.g., PyMOL, MOE, VMD)
• Molecular dynamics methodology and software (e.g., GROMACS, NAMD, Amber)
• Linux shell scripting and Python

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.

#LI-Onsite

Required Skills:

Preferred Skills: